Anti-ADAM17 (human) (blocking), clone D1(A12)

Anti-ADAM17 (human) (blocking), clone D1(A12)
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-27B-6000PF-C100 100 µg -

3 - 9 business days*

10 %
572.00€
514.80€
 
Protein function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.... more
Product information "Anti-ADAM17 (human) (blocking), clone D1(A12)"
Protein function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. [The UniProt Consortium] This cross-domain human antibody is a selective ADAM17 (TACE) antagonist and provides a unique alternative to small molecule metalloprotease inhibition. ADAM multidomain topology was exploited by first isolating an inhibitory human antibody (D1) that bound ADAM17-specific non-catalytic regions exclusively through its variable heavy (VH) domain. A D1-VH biased scFv phage-display library was then used to selectively isolate a new variable light (VL) chain that could simultaneously bind to the ADAM17 catalytic domain.
Keywords: Anti-CSVP, Anti-ADAM17, Anti-CD156b, Anti-ADAM 17, EC=3.4.24.86, Anti-TNF-alpha convertase, Anti-Snake venom-like protease, Anti-TNF-alpha-converting enzyme, Anti-Disintegrin and metalloproteinase domain-containing protein 17
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-27B-6000PF

Properties

Application: FA (blocking)
Antibody Type: Monoclonal
Clone: D1(A12)
Conjugate: No
Host: Human
Species reactivity: human
Immunogen: Recombinant human ADAM17 (TACE) ectodomain tagged to biotin
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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