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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A0856-05E.500 | 500 µg | - | - |
3 - 19 business days* |
1,189.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activin isoforms and other members of the TGFbeta superfamily exert their biological effects by... more
Product information "Anti-Activin Receptor Type IIA (RIIA)"
Activin isoforms and other members of the TGFbeta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serinethreonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActRI(A), ActRIB, ActRII(A) and ActRIIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActRIIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different highaffinities to the various type II isoforms. Type I activin receptors do not bind directly to activin, but will associate with the type II receptoractivin complex and initiate signal transduction. Besides the activin isoforms, ActRII will also bind inhibin, BMP2 and BMP7 with lower affinities. ActRI can also bind and form signaling complexes with the BMP2/7bound BMPRII. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml using human testis tissue., Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-ACVR2, Anti-ACVR2A, Anti-ACTRIIA, Anti-ACTR-IIA, EC=2.7.11.30, Anti-Activin receptor type-2A, Anti-Activin receptor type IIA |
Supplier: | United States Biological |
Supplier-Nr: | A0856-05E |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | 9H20 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Sf 21-derived, recombinant human Activin receptor IIA extracellular domain. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04670 | Matching products |
UniProt ID : | P27037 | Matching products |
Gene ID | GeneID 92 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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