Anti-Activin Receptor Type IIA (RIIA)

Anti-Activin Receptor Type IIA (RIIA)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A0856-05E.500 500 µg - -

3 - 19 business days*

830.00€
 
Activin isoforms and other members of the TGF­beta superfamily exert their biological effects by... more
Product information "Anti-Activin Receptor Type IIA (RIIA)"
Activin isoforms and other members of the TGF­beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine­threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR­I(A), ActR­IB, ActR­II(A) and ActR­IIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActR­IIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different high­affinities to the various type II isoforms. Type I activin receptors do not bind directly to activin, but will associate with the type II receptor­activin complex and initiate signal transduction. Besides the activin isoforms, ActR­II will also bind inhibin, BMP­2 and BMP­7 with lower affinities. ActR­I can also bind and form signaling complexes with the BMP­2/7­bound BMPR­II. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml using human testis tissue., Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-ACVR2, Anti-ACVR2A, Anti-ACTRIIA, Anti-ACTR-IIA, EC=2.7.11.30, Anti-Activin receptor type-2A, Anti-Activin receptor type IIA
Supplier: United States Biological
Supplier-Nr: A0856-05E

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 9H20
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Sf 21-derived, recombinant human Activin receptor IIA extracellular domain.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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