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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A0855-95B.100 | 100 µg | - | - |
3 - 19 business days* |
991.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activins are dimeric growth and differentiation factors which belong to the transforming growth... more
Product information "Anti-Activin Receptor Type IA (ALK-2, RIA)"
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. Unlike ACVR1B and ACVR1C, ACVR1, also known as activin receptor-like kinase 2 (ALK2), can not transduce activin-mediated signaling, but will transduce BMP and Mullerian inhibiting substance (MIS) group signaling. It is thought that ACVR1 also inhibits activin signaling by blocking the binding of activin to its type II receptor. Recent studies indicate that genetic variation in ACVR1 is associated with polycystic ovary syndrome, suggesting that ACVR1 signaling contributes to disturbed folliculogenesis in these patients. At least four isoforms of ACVR1 are known to exist. This antibody is predicted to have no crossreactivity to ACVR1B or ACVR1C. Applications: Suitable for use in Flow Cytometry, Direct ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 2.5ug/10e6 cells using PC-3 human prostate cancer cell line, Western Blot: 0.1ug/ml using recombinant human Activin RIA/ALK-2 Fc Chimera, Immunohistochemistry (Paraffin): 5-15ug/ml using immersion fixed paraffin-embedded sections of human astrocytoma and human placenta, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-SKR1, Anti-ACVR1, Anti-TSR-I, Anti-ALK-2, Anti-ACTR-I, Anti-ACVRLK2, EC=2.7.11.30, Anti-Activin receptor type-1, Anti-Activin receptor type I, Anti-Activin receptor-like kinase 2, Anti-TGF-B superfamily receptor type I |
Supplier: | United States Biological |
Supplier-Nr: | A0855-95B |
Properties
Application: | ELISA, FC, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Goat |
Species reactivity: | human |
Immunogen: | Recombinant human Activin RIA extracellular domain. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04675 | Matching products |
UniProt ID : | Q04771 | Matching products |
Gene ID | GeneID 90 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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