Anti-Activin A receptor type IC (ACVR1C, Activin receptor-like kinase 7, Activin receptor type 1C pr

Anti-Activin A receptor type IC (ACVR1C, Activin receptor-like kinase 7, Activin receptor type 1C pr
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A0855-92.100 100 µg - -

3 - 19 business days*

511.00€
 
Activins are dimeric growth and differentiation factors which belong to the transforming growth... more
Product information "Anti-Activin A receptor type IC (ACVR1C, Activin receptor-like kinase 7, Activin receptor type 1C pr"
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1B. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml , Optimal dilutions to be determined by the researcher. Positive Control: Human Placenta Lysate, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: EC=2.7.11.30, Anti-Activin receptor type IC, Anti-Activin receptor type-1C
Supplier: United States Biological
Supplier-Nr: A0855-92

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to 15aa from near the amino terminus of the human ACVR1C.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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