Anti-ACE2, CT (Angiotensin-converting Enzyme 2, ACE-related Carboxypeptidase, Angiotensin-converting

Anti-ACE2, CT (Angiotensin-converting Enzyme 2, ACE-related Carboxypeptidase, Angiotensin-converting
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A2295-02D5-APC.200 200 µl - -

3 - 19 business days*

799.00€
 
ACE2 cDNA encodes a deduced 805aa protein containing a potential 17aa N-terminal signal peptide... more
Product information "Anti-ACE2, CT (Angiotensin-converting Enzyme 2, ACE-related Carboxypeptidase, Angiotensin-converting"
ACE2 cDNA encodes a deduced 805aa protein containing a potential 17aa N-terminal signal peptide and a putative 22aa C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin I to angiotensin II, ACE2 converts angiotensin I to angiotensin 1-9, which has 9aa. Angiotensin II is a potent blood vessel constrictor, while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a blood vessel dilator. Spike (S) proteins of coronaviruses, including the SARS coronavirus, bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor for SARS coronavirus. Applications: Suitable for use in FLISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-1:500, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Keywords: Anti-ACE2, EC=3.4.17.23
Supplier: United States Biological
Supplier-Nr: A2295-02D5-APC

Properties

Application: FLISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: APC
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide selected from the C-terminal region of human ACE2 (KLH).
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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