Anti-ACE2, clone AC18F

Anti-ACE2, clone AC18F
Anti-ACE2, clone AC18F
   
COVID-19 Research
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG42475.50 50 µg - -

6 - 14 business days*

532.00€
ARG42475.100 100 µg - -

6 - 14 business days*

764.00€
 
Protein function: Essential counter-regulatory carboxypeptidase of the renin- angiotensin hormone... more
Product information "Anti-ACE2, clone AC18F"
Protein function: Essential counter-regulatory carboxypeptidase of the renin- angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1- 9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042, PubMed:10924499, PubMed:11815627, PubMed:19021774, PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin- 7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). [The UniProt Consortium]
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG42475

Properties

Application: ELISA, FC, WB
Antibody Type: Monoclonal
Clone: AC18F
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant Human ACE2
MW: 92 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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