Anti-ABCB5 (ATP-binding cassette, sub-family B MDR/TAP, ABCB5alpha, ABCB5beta, EST422562, ATP-bindin

Anti-ABCB5 (ATP-binding cassette, sub-family B MDR/TAP, ABCB5alpha, ABCB5beta, EST422562, ATP-bindin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
029928.100 100 µg - -

3 - 19 business days*

505.00€
 
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane... more
Product information "Anti-ABCB5 (ATP-binding cassette, sub-family B MDR/TAP, ABCB5alpha, ABCB5beta, EST422562, ATP-bindin"
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules , ABCB5 (ATP-binding cassette, subfamily B [DR/TAP] member 5) is a 90kD (predicted MW) member of the human P-glycoprotein family of molecules. It is expressed by CD133+ pluripotent pigment stem cells, where it serves as a marker for cells that show a high incidence of polyploidy. Human ABCB5 is 812aa in length. It is possibly a five transmembrane protein with a 247aa N-terminal extracellular domain (ECD) aa1-247 and a 283aa C-terminal cytoplasmic region aa530-812. The ECD contains one ABC transporter aa2-177, while the cytoplasmic region contains a second ABC transporter aa570-808. There are two potential splice forms. One shows a seven aa substitution for aa125-812, while another possesses an alternative start site 445aa upstream of the standard site. Over aa141-247, human ABCB5 shares 64aa identity with mouse ABCB5. Applications: Western Blot: 1:500-1:2000 Immunohistochemistry: 1:200-1:1000, Immunocytochemistry: 1:200-1:1000, Flow Cytometry: 1:200-1:400, ELISA: 1:10000, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-ABCB5, Anti-ABCB5 P-gp, Anti-P-glycoprotein ABCB5, Anti-ATP-binding cassette sub-family B member 5
Supplier: United States Biological
Supplier-Nr: 029928

Properties

Application: ELISA, FC, ICC, IHC, WB
Antibody Type: Monoclonal
Clone: 13B6
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Purified recombinant fragment of human ABCB5 (AA: 481-674) expressed in E. coli.

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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