Protein function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. [The UniProt Consortium]
Anti-SMG8, Anti-ABC2, Anti-Protein SMG8, Anti-Protein smg-8 homolog, Anti-Amplified in breast cancer gene 2 protein
synthetic peptide. The epitope recognized by A301-471A-T maps to a region between residue 250 and 300 of human amplified in breast cancer gene 2 protein using the numbering given in entry NP_060619.4 (GeneID 55181).