Anti-4-1BB Receptor, PE conjugated (CD137, TNFRSF9, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homol

Anti-4-1BB Receptor, PE conjugated (CD137, TNFRSF9, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homol
Item number Size Datasheet Manual SDS Delivery time Quantity Price
0004-01L.100 100 tests - -

3 - 19 business days*

567.00€
 
4-1BB is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is... more
Product information "Anti-4-1BB Receptor, PE conjugated (CD137, TNFRSF9, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homol"
4-1BB is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFRSF9, CD137, and ILA. The 255aa human 4-1BB is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30kD glycoprotein exists both as a , monomer and as a dimer on T cells. The human and mouse proteins share 60% aa identity. 4-1BB is absent from naive T cells, but it is upregulated and continually expressed following T cell activation. The natural ligand, 4-1BBL, is a member of the TNF superfamily and is expressed on activated antigen presenting cells including dendritic cells, macrophages, and B cells. Cross- linking of 4-1BB by 4-1BBL or by agonistic antibodies transmits a potent co-stimulatory signal that enhances the effect of other activating signals such as PHA or anti-CD3 antibodies. 4-1BB signals through the TFAF2-NIK pathway resulting in activation of NF-kB and ultimately promoting proliferation and survival of T cells. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: 0004-01L

Properties

Application: FC
Antibody Type: Monoclonal
Clone: 9H3
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Synthetic peptide
Format: Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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