Anti-3pK

Anti-3pK
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-305A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A304-305A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A304-305A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Stress-activated serine/threonine-protein kinase involved in cytokines... more
Product information "Anti-3pK"
Protein function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38- alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. [The UniProt Consortium]
Keywords: Anti-3pK, Anti-MK-3, Anti-MAPKAPK3, Anti-MAPKAPK-3, Anti-MAPKAP-K3, EC=2.7.11.1, Anti-MAPKAP kinase 3, Anti-Chromosome 3p kinase, Anti-MAPK-activated protein kinase 3, Anti-MAP kinase-activated protein kinase 3
Supplier: Bethyl Laboratories
Supplier-Nr: A304-305A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A304-305A-T maps to a region between residue 1 to 50 of human Chromosome 3p Kinase using the numbering given in entry NP_001230855.1 (GeneID 7867).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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