1,2-Dioleoyl-3-trimethylammoniumpropane (chloride)

1,2-Dioleoyl-3-trimethylammoniumpropane (DOTAP) is a cationic liposome-forming compound used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells. It has been used in the composition of small unilamellar liposomes formulated as a gene delivery vectors for gene therapy.Formal Name: N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-1-propanaminium, monochloride. CAS Number: 132172-61-3. Synonyms: DOTAP. Molecular Formula: C42H80NO4 . Cl. Formula Weight: 698.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 0.5 mg/ml, Ethanol: 33 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. SMILES: CCCCCCCC/C=C\CCCCCCCC(OC(C[N+](C)(C)C)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-]. InChi Code: InChI=1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2,/h20-23,40H,6-19,24-39H2,1-5H3,1H/q+1,/p-1/b22-20-,23-21-,. InChi Key: KSXTUUUQYQYKCR-LQDDAWAPSA-M.