Products from LKT Laboratories
LKT Laboratories, Inc., in St. Paul, Minnesota, is a research and development company focussing on the synthesis, purification and isolation of small molecules. Established in 1989, LKT Labs produces and markets unique (bio-)chemicals for all types of life science research, especially for the fields of cancer and neuroscience. The products include protein kinase inhibitors as well as ion channel modulators and are used for various research applications.
More information at: www.lktlabs.com
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25-Hydroxyvitamin D3
Item number: LKT-H9815.1
25-hydroxyvitamin D3 (25-OH D3), or calcidiol/calcifediol, is a pro-hormone for calcitriol that restores bone mineralization in vitamin D-deficient models. 25-OH D3 is the major circulating metabolite of vitamin D3. Vitamin D signaling also regulates Ca2+ homeostasis. 25-OH D3 activates the vitamin D receptor and...
| Keywords: | Calcifediol, calcidiol, 25-hydroxycholecalciferol |
| Application: | Vitamin D3 metabolite |
| CAS | 19356-17-3 |
| MW: | 400,64 D |
From 175.00€
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Y27632 dihydrochloride
Item number: LKT-Y1000.25
Y27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), Y27632 binds to the catalytic site of ROCK, preventing binding of Ras-related GTPase Rho A, which is involved in actin cytoskeleton reorganization, cell adhesion, and cell migration. Y27632 inhibits downstream endothelin and TGF- -related...
| Application: | ROCK inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.26 D |
From 121.00€
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Indirubin
Item number: LKT-I5212.5
Indirubin is a bisindole isomer of indigo, naturally sourced from Indigo naturalis. Indirubin exhibits anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. In vivo, indirubin decreases levels of IgE and production of inflammatory cytokines, decreasing overall inflammation as well as skin...
| Application: | CDK inhibitor |
| CAS | 479-41-4 |
| MW: | 262.26 D |
From 104.00€
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Phenethyl caffeate
Item number: LKT-P2400.50
An active ingredient of honeybee hive products, propolis. Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Induces apoptosis, modulates redox state of cells and suppresses acute inflammation.
| Keywords: | 3,4-Dihydroxycinnamic acid phenethyl ester, caffeic acid phenethyl ester, CAPE |
| Application: | Tyrosine kinase inhibitor |
| CAS | 104594-70-9 |
| MW: | 284,31 D |
From 118.00€
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Benztropine mesylate
Item number: LKT-B1955.1
Benztropine is an inhibitor of the dopamine transporter (DAT), it potentiates dopamine overflow in rat brain slices.
| Application: | Muscarinic cholinergic receptor antagonist, Dopamine transporter inhibitor |
| CAS | 132-17-2 |
| MW: | 403.53 D |
From 90.00€
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ABT-263
Item number: LKT-A0777.5
ABT-263 is a BH3 mimetic that inhibits Bcl-2 and Bcl-xl. ABT-263's inhibition of Bcl-xl results in thrombocytopenia, limiting its usage. ABT-263 exhibits anticancer chemotherapeutic activity and shows some benefit in clinical trials. In chronic lymphocytic leukemia (CLL) cells, ABT-263 inhibits cell proliferation....
| Keywords: | Navitoclax, A-855071 |
| Application: | BH3 mimetic, Bcl-2 / Bcl-xl inhibitor |
| CAS | 923564-51-6 |
| MW: | 974.61 D |
From 108.00€
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Serum Thymic Factor
Item number: LKT-S1970.1
A thymic peptide hormone that induces the formation of E rosettes.
| Application: | Metabolic studies |
| MW: | 858,89 D |
From 108.00€
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Thymosin alpha-1 Acetate
Item number: LKT-T3097.10
Endogenous peptide, involved in hormone regulation.
| Application: | Antineoplastic, Hepatitis treatment, Infectious disease treatment, Vaccine enhancement |
| CAS | 62304-98-7 |
| MW: | 3108.3 D |
From 90.00€
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Primaquine phosphate
Item number: LKT-P7033.10
An antimalarial drug with genotoxicity (Ames test) and cardiotoxicity (inhibitor of cardiac Na current).
| Keywords: | Primaquine diphosphate |
| Application: | Na current inhibitor |
| CAS | 63-45-6 |
| MW: | 455,29 D |
From 108.00€
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Proxymetacaine hydrochloride
Item number: LKT-P7059.100
A local anesthetic that is used to numb the surface of a body part.
| Application: | Sodium channel blocking |
| CAS | 499-67-2 |
| MW: | 294,39 D |
From 84.00€
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