Products from Innaxon
Innaxon is a company based in Tewkesbury, United Kingdom focussing on innate immunity, Toll-like Receptor (TLR) agonists and small molecule inhibitors. Innaxon develops and manufactures defined “Immunoceuticals” of the highest activity and purity for pre-clinical research and development applications for vaccine adjuvants and immunotherapy. Their unique biological and synthetic TLR ligands are well-characterized and effective biological response modifiers of inappropriate or disproportionate immune responses.
More information at: www.adipogen.com/innaxon
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ODN 2395 (Type C) Endotoxin-free (sterile)
Item number: IAX-200-007-C100
Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.7-7.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Keywords: | CpG ODN: C Type (species: human and rodent) |
| Application: | TLR9 activator |
| MW: | 7068 D |
From 218.00€
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iODN (inhibitory ODN) (ttaggg)4 Endotoxin-free (sterile)
Item number: IAX-200-051-C100
Potent sequence of an inhibitory ODN for in vivo use in rodents (100-300 µg per injection), prototype class II, inhibits STAT signaling, independent of TLR signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Keywords: | Inhibitory ODN (iODN): Class II |
| Application: | STAT signaling inhibitor |
| MW: | 8288 D |
From 179.00€
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Mini-iODN (inhibitory ODN) Endotoxin-free (sterile)
Item number: IAX-200-053-C100
Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150 µg per injection): prototype class I, may also affect TLR7 and TLR8 signaling. egative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Keywords: | Inhibitory ODN (iODN): Class I |
| Application: | TLR9 competitor |
| MW: | 3584 D |
179.00€
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Mega-iODN (inhibitory ODN) Endotoxin-free (sterile)
Item number: IAX-200-054-C100
Particularly potent sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): based on class I (ODN H154) and class II (ODN A151) sequences to combine inhibitory activity on TLRs and STAT signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Keywords: | Inhibitory ODN (iODN): Class I/II |
| Application: | TLR9 competitor |
| MW: | 5894 D |
179.00€
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Duo-iODN (inhibitory ODN) Endotoxin-free (sterile)
Item number: IAX-200-055-C100
Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): prototype class I that also inhibits TLR7 signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Keywords: | Inhibitory ODN (iODN): Class I |
| Application: | TLR9 competitor |
| MW: | 5867 D |
From 179.00€
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ODN 2218 (Control for ODN 1585) Endotoxin-free (sterile)
Item number: IAX-200-203-C100
Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN M362 (Cat. No.: IAX-200-004). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
| Application: | Negative Control for ODN M362 (IAX-200-004) |
| MW: | 8073 D |
179.00€
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ODN M383 (Control for ODN M362) Endotoxin-free (sterile)
Item number: IAX-200-204-C100
Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN 2216 (Cat. No.: IAX-200-005). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
| Application: | Negative Control for ODN 2216 (IAX-200-005) |
| MW: | 8073 D |
179.00€
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TLR7-iODN (inhibitory ODN) Endotoxin-free (sterile)
Item number: IAX-200-056-C100
In recent years several groups have studied the sequence requirements, specificity, signaling pathways and kinetics of the TLR (Toll-like receptor) 9 suppression by inhibitory oligonucleotide motifs, which led to a class of novel inhibitory oligonucleotide (iODNs), that is independent of the previously thought...
| Keywords: | Inhibitory ODN (iODN): Class I/III, ODN immunoregulatory sequence 661 (IRS661) |
| Application: | Immune modulator |
| MW: | 6761 D |
From 179.00€
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CTRL2-ODN (Control for iODN and CpG-ODNs) Endotoxin-free...
Item number: IAX-200-208-C100
Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in...
| Keywords: | CTRL ODN 2, Negative Control for inhibitory ODNs (iODNs) and CpG ODNs (TLR9 agonists) |
| Application: | Immune modulator |
| Species reactivity: | human, mouse, rat |
| MW: | 7324 D |
From 179.00€
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Physiological Saline [Sodium Chloride 0.9%]...
Item number: IAX-900-003-3010
Chemical. Use for the dilution of TLRpureTM LPS and solubilisation of endotoxin-free reagents (e.g. ODNs).
| Keywords: | Sodium Chloride 0.9% |
| CAS | 7647-14-5 |
From 34.00€
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ddWater Endotoxin-free (sterile)
Item number: IAX-900-002-LD15
Chemical. Endotoxin free diluent buffer used for the dilution of TLRpure LPS, MPLA and Lipid A and solubilisation of endotoxin-free reagents (e.g. ODNs).
| Keywords: | double-distilled Water |
| CAS | 7732-18-5 |
| MW: | 18 D |
From 34.00€
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PBS Endotoxin-free (sterile)
Item number: IAX-900-001-L010
Chemical. Endotoxin free buffer used for the dilution of TLRpure LPS and solubilisation of endotoxin-free reagents (e.g. ODNs).
| Keywords: | Phosphate Buffer Saline Endotoxin-free (sterile) |
From 34.00€
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