Products from Innaxon
Innaxon is a company based in Tewkesbury, United Kingdom focussing on innate immunity, Toll-like Receptor (TLR) agonists and small molecule inhibitors. Innaxon develops and manufactures defined “Immunoceuticals” of the highest activity and purity for pre-clinical research and development applications for vaccine adjuvants and immunotherapy. Their unique biological and synthetic TLR ligands are well-characterized and effective biological response modifiers of inappropriate or disproportionate immune responses.
More information at: www.adipogen.com/innaxon
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ODN M362 (Type C) Endotoxin-free (sterile)
Item number: IAX-200-004-M001
Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2243 (Cat. No.: IAX-200-205).
| Keywords: | CpG ODN TLR9 Agonist: A Type (species: human and rodent) |
| Application: | TLR9 activator |
| MW: | 6644 D |
From 218.00€
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ODN 1720 (Control for ODN 1668) Endotoxin-free (sterile)
Item number: IAX-200-200-C100
Negative control GpC ODN for use in rodents (50-150 µg per injection). As active compound use CpG ODN 1668 (Cat. No.: IAX-200-001). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
| Application: | Negative Control for ODN 1668 (IAX-200-001) |
| MW: | 6383 D |
179.00€
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![Monophosphoryl Lipid A [MPLA] from E. coli R515 (Re) TLRpure Sterile Solution](https://www.biomol.com/media/image/9d/92/86/IAX-100-003-M001_200x200.png "Monophosphoryl Lipid A [MPLA] from E. coli R515 (Re) TLRpure Sterile Solution")
Monophosphoryl Lipid A [MPLA] from E. coli R515 (Re)...
Item number: IAX-100-003-M001
Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.1-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4), a member of the highly...
| Keywords: | Monophosphoryl Lipid A [MPLA] derived from E. coli R515 (Re) LPS (biosynthetic) |
| Application: | TLR4 activator |
From 205.00€
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G-type iODN (inhibitory ODN) Endotoxin-free (sterile)
Item number: IAX-200-052-M001
Potent sequence of an inhibitory ODN of the poly-G class I targeting TLR9, but without effect on TLR7 and TLR8 signaling, for in vivo use in rodents (50-150 µg per injection). Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
| Keywords: | Inhibitory ODN (iODN): Class I |
| Application: | TLR9 competitor |
| MW: | 6735 D |
From 179.00€
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LPS from S. typhimurium (S-form) TLRpure Sterile Solution
Item number: IAX-100-011-M001
Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.01-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal...
| Keywords: | Lipopolysaccharide (LPS) from Salmonella typhimurium, S-type (smooth/wild-type) LPS |
| Application: | TLR4 activator |
From 175.00€
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![Trehalose 6,6'-dimycolate (TDM) [Cord Factor] Endotoxin-free (sterile)](https://www.biomol.com/media/image/85/0d/b0/IAX-200-101-M001_200x200.jpg "Trehalose 6,6'-dimycolate (TDM) [Cord Factor] Endotoxin-free (sterile)")
Trehalose 6,6'-dimycolate (TDM) [Cord Factor]...
Item number: IAX-200-101-C100
To stimulate mouse bone marrow-derived macrophages, Cord Factor was suspended at a concentration of 0.2 mg/ml in hexane. Of the resulting solution 1 or 10 µg/well were layered in 96-well tissue culture plates and the solvent completely evaporated. Control wells were layered with solvent without Cord Factor and also...
| Keywords: | TDM, CF |
| Application: | Mycobacterial glycolipid |
| CAS | 61512-20-7 |
307.00€
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IAXO-101 (CD14/TLR4 Antagonist) (synthetic)
Item number: IAX-600-001-M001
Described to interfere with human, rat and mouse TLR4/CD14 signaling, other species not tested. Optimal working concentration depends upon the type, purity and concentration and of TLR4 ligand, carrier protein such as LPS-binding protein (LBP), soluble and membrane-bound CD14, the presence of TLR4 co-receptors (e.g....
| Keywords: | Methyl 6-deoxy-6-N-dimethyl-N-cyclopentylammonium-2,3-di-O-tetradecyl-?-D-glucopyranoside iodide |
| Application: | CD14/TLR4 Antagonist |
| CAS | 1202388-64-4 |
| MW: | 810.02 D |
347.00€
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LPS (Universal) from S. abortus equi (S-form) TLRpure...
Item number: IAX-100-009-M001
Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.01-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal...
| Keywords: | Lipopolysaccharide (LPS) from Salmonella abortus equi, S-type (smooth/wild-type) LPS |
| Application: | TLR4 activator |
From 157.00€
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LPS from E. coli O111:B4 (S-form) TLRpure Sterile Solution
Item number: IAX-100-012-M001
Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.01-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal...
| Keywords: | Lipopolysaccharide (LPS) from E. coli O111:B4, S-type (smooth/wild-type) LPS |
| Application: | TLR4 activator |
From 294.00€
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LPS from E. coli O55:B5 (S-form) TLRpure Sterile Solution
Item number: IAX-100-013-M001
Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.01-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal...
| Keywords: | Lipopolysaccharide (LPS) from E. coli O55:B5, S-type (smooth/wild-type) LPS |
| Application: | TLR4 activator |
From 294.00€
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ODN 1826 (Type B) Endotoxin-free (sterile)
Item number: IAX-200-002-M001
3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 1982 (Cat. No.: IAX-200-201).
| Keywords: | CpG ODN TLR9 Agonist: B Type (species: rodent) |
| Application: | TLR9 activator |
| Species reactivity: | mouse, rat |
| MW: | 6383 D |
From 218.00€
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ODN 2006 (Type B) Endotoxin-free (sterile)
Item number: IAX-200-006-C100
3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.7-7.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2137 (Cat. No.: IAX-200-206).
| Keywords: | CpG ODN TLR9 Agonist: B Type (species: human and rodent) |
| Application: | TLR9 activator |
| MW: | 7720 D |
From 218.00€
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