Produkte von TargetMol
TargetMol aus Boston (Massachusetts) wurde 2015 gegründet und ist ein Experte für Wirkstoffscreening in der Life Science-Community. Das Unternehmen bietet diverse Substanzbibliotheken, darunter FDA-zugelassene Bibliotheken, an und deckt ein breites Spektrum an niedermolekularen Verbindungen wie Inhibitoren und Agonisten sowie rekombinante Proteine und Naturstoffe ab. Die Produkte von TargetMol werden von Forschenden weltweit in Bereichen wie Krebsforschung, Neurobiologie, Inflammation, Immunologie oder Metabolismus eingesetzt.
Mehr Informationen unter: www.targetmol.com
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-inflammatory agent 9
Artikelnummer: TGM-T61400-100mg
Description: Anti-inflammatory agent 9 (compound 28) is a benzimidazothiazole derivative derived from tilomisole, exhibiting higher COX-2 enzyme affinity than COX-1, thereby demonstrating promising anti-inflammatory properties and oral bioavailability [1]. Target: Others
| MW: | 365.41 D |
ab 1.440,00 €
BChE-IN-2
Artikelnummer: TGM-T61408-100mg
Description: BChE-IN-2 (compound 22) is a highly effective inhibitor of BChE, with a Ki value of 0.099 µM, and represents a promising pyrimidine and pyridine derivative for investigating Alzheimer's disease (AD). [1]. Target: Others
| MW: | 365.52 D |
ab 1.440,00 €
CXCR4 antagonist 3
Artikelnummer: TGM-T61409-100mg
Description: CXCR4 antagonist 3 (compound 12a), an effective antagonist of CXCR4, exhibits an IC50 of 11 nM. It is a congener of TIQ15, showcasing exceptional properties such as CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. With its potential for research on the human immunodeficiency...
| MW: | 365.52 D |
ab 1.440,00 €
FLT3/ITD-IN-1
Artikelnummer: TGM-T61415-100mg
Description: FLT3/ITD-IN-1 (Compound 1) is a highly potent inhibitor of FLT3 internal tandem duplications (FLT3-ITD) with IC50 values of 38.2 nM for FLT3 and 144.1 nM for FLT3-ITD, and shows exceptional antiproliferative activities against several acute myeloid leukemia cell lines [1]. Target: Others
| MW: | 366.42 D |
ab 1.440,00 €
Transthyretin-IN-1
Artikelnummer: TGM-T61423-100mg
Description: Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer's disease [1]. Target: Others
| MW: | 366.99 D |
ab 1.440,00 €
NOS-IN-2
Artikelnummer: TGM-T61426-100mg
Description: NOS-IN-2 (Compound 4i), an imidamide-derived NOS inhibitor, exhibits high potency and selectivity, specifically inhibiting iNOS with an IC50 of 20 µM while sparing eNOS. Demonstrating minimal toxicity, it is suitable for research on inflammatory disorders [1]. Target: Others
| MW: | 367.37 D |
ab 1.440,00 €
HDAC-IN-33
Artikelnummer: TGM-T61429-100mg
Description: HDAC-IN-33 is a highly potent HDAC inhibitor, effectively inhibiting HDAC1, HDAC2, and HDAC6 with IC50 values of 24, 46, and 47 nM, respectively. This compound demonstrates significant antiproliferation activity against tumor cells and exhibits remarkable in vivo antitumor efficacy. Additionally,...
| MW: | 367.44 D |
ab 1.440,00 €
Topoisomerase IIalpha-IN-4
Artikelnummer: TGM-T61431-100mg
Description: Topoisomerase IIalpha-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, selectively inhibiting TopoIIalpha with an IC50 value of 3.8 µM and TopoIIbeta with an IC50 value of 10.1 µM. It induces apoptosis and arrests the cell cycle in HepG2 cells, demonstrating...
| MW: | 367.44 D |
ab 1.440,00 €
HDAC1-IN-5
Artikelnummer: TGM-T61433-100mg
Description: HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 and alpha-tubulin, leading to the activation of caspase 3 and induction of apoptosis....
| MW: | 367.46 D |
ab 1.440,00 €
HIF-1/2alpha-IN-1
Artikelnummer: TGM-T61442-100mg
Description: HIF-1/2alpha-IN-1, an orally active compound, functions as an inhibitor of HIF-2alpha. Its inhibitory effect on HIF-2alpha activity is significant, with an IC 50 value of 0.92 µM. Furthermore, HIF-1/2alpha-IN-1 has the ability to decrease HIF-1alpha levels. This compound is particularly valuable for...
| MW: | 368.35 D |
ab 1.440,00 €
Trk-IN-7
Artikelnummer: TGM-T61443-100mg
Description: Trk-IN-7 (compound I-6) is a highly potent TRK inhibitor, with IC50 values of 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. It also shows significant inhibition of EML4-ALK (IC50 <15 nM) and ALK mutations G1202R, C1156Y, R1275Q, F1174L, L1197M, and G1269A (IC50 = 5-50 nM) [1]. Target: Others
| MW: | 368.36 D |
ab 1.440,00 €
Nonsteroidal aromatase inhibitor 1
Artikelnummer: TGM-T61444-100mg
Description: Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. This potent inhibitory activity suggests its potential for breast cancer research [1]. Target: Others
| MW: | 368.39 D |
ab 1.440,00 €