Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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GSK-F1
Artikelnummer: SYN-1220-M001
Solid. Soluble in DMSO. GSK-F1 is a potent PI4KA inhibitor. It has better pharmacokinetic properties in vivo than to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type III? (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for...
| Schlagworte: | 5-(2-Amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulf... |
| Anwendung: | Potent PI4KA inhibitor |
| CAS | 1402345-92-9 |
| MW: | 603,5 D |
ab 158,00 €
Regorafenib
Artikelnummer: SYN-1169-M100
Soluble in DMSO or ethanol. Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR beta, Kit, RET and Raf-1 with IC(50) values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively. Target: VEGFR , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | BAY-73-4506 |
| Anwendung: | VEGFR2 / RET / Raf-1 inhibitor |
| CAS | 755037-03-7 |
| MW: | 482,8 D |
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CX-5461
Artikelnummer: SYN-3031-M001
Slightly soluble (<1mg/ml) in DMSO or ethanol. CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
| Schlagworte: | Chantix, Champix |
| Anwendung: | RNA polymerase I inhibitor |
| CAS | 1138549-36-6 |
| MW: | 513.6 D |
ab 119,00 €
(R)-BI-2536
Artikelnummer: SYN-1019-M001
Soluble in DMSO, Ethanol. Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple...
| Schlagworte: | (R)-BI2536 |
| Anwendung: | PLK1 inhibitor |
| CAS | 755038-02-9 |
| MW: | 521,7 D |
ab 106,00 €
TAE-684
Artikelnummer: SYN-1159-M001
Soluble in DMSO or ethanol. TAE684 is a potent and selective ALK inhibitor with an IC(50) of 3nM. It is 100-fold more sensitive for ALK over InsR. Target: ALK , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | NVP-TAE684 |
| Anwendung: | ALK inhibitor |
| CAS | 761439-42-3 |
| MW: | 614,2 D |
ab 119,00 €
GSK-A1
Artikelnummer: SYN-1219-M001
Solid. Soluble in DMSO. GSK-A1 is a potent PI4KA inhibitor with an IC50 of about 3nM in vitro using HEK-AT1 cells. Phosphatidylinositol 4-kinase type III? (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory...
| Schlagworte: | 5-(2-Amino-1-(4-morpholinophenyl)-1H-benzo[d]imidazol-6-yl)-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide, GSKA1 |
| Anwendung: | Potent PI4KA inhibitor |
| CAS | 1416334-69-4 |
| MW: | 574,6 D |
ab 158,00 €
LY2801653
Artikelnummer: SYN-1222-M005
Solid. Soluble in DMSO. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R and other oncoproteins. It displays anti-tumour activities in mouse xenograft models. In vitro, LY2801653 has an IC50 for inhibition of MET phosphorylation between 35.2-59.2nM. LY2801653 was...
| Schlagworte: | LY-2801653,... |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 1206799-15-6 |
| MW: | 552,5 D |
ab 106,00 €
Erlotinib hydrochloride
Artikelnummer: SYN-1039-M001
Soluble in DMSO. Slightly soluble ( 1000-fold more sensitive for EGFR than for c-Src or v-Abl. Target: EGFR , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | OSI774, CP-358774, Tarceva, NSC718781 |
| Anwendung: | EGFR inhibitor |
| CAS | 183319-69-9 |
| MW: | 429,9 D |
ab 66,00 €
GW-441756
Artikelnummer: SYN-1044-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GW441756 is an orally active, potent and highly selective TrkA tyrosine kinase inhibitor (IC(50) of 2nM). It specifically blocks TrkA-induced cell death in a dose-dependent manner. Target: TrkA , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | GW441756 |
| Anwendung: | TrkA inhibitor |
| CAS | 504433-23-2 |
| MW: | 275,3 D |
ab 79,00 €
PF-4618433
Artikelnummer: SYN-1163-M001
Soluble in DMSO. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent...
| Schlagworte: | PF4618433 |
| Anwendung: | PYK2 inhibitor |
| CAS | 1166393-85-6 |
| MW: | 445,5 D |
ab 250,00 €
BKM-120
Artikelnummer: SYN-1200-M005
Soluble in DMSO or ethanol. NVP-BKM120 is a potent, selective, orally bioavailable Class I PI3Kalpha Inhibitor with IC(50) of 20nM, currently in Phase II clinical trials for the treatment of cancer. It exhibits lower potency against class III and class IV PI3Ks Target: PI3K , Kinase Group: Lipid Kinase ,...
| Schlagworte: | NVP-BKM120 |
| Anwendung: | PI3K inhibitor |
| CAS | 944396-07-0 |
| MW: | 410,4 D |
ab 79,00 €
GSK-2606414
Artikelnummer: SYN-1201-M001
Soluble in DMSO or ethanol. GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC(50) of 0.4nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed Target: PERK , Kinase Group: Other , Substrate: Serine-Threonine
| Schlagworte: | GSK-2606414 |
| Anwendung: | EIF2AK3 / PERK inhibitor |
| CAS | 1337531-36-8 |
| MW: | 451,4 D |
ab 119,00 €