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Rheb Inhibitor NR1
Artikelnummer: Cay43360-1
A Rheb inhibitor, inhibits Rheb-dependent mTORC1 activity (IC50 = 2.1 µM), selectively inhibits Rheb-depedent mTORC1 activity over Rheb-independent mTORC1 activity, mTORC2, Ras, and Rap1 at 30 µM, decreases the size of Jurkat T cells and inhibits protein synthesis in MCF-7 breast cancer cells at 10 µM, inhibits the...
| Schlagworte: | 4-bromo-6-[(3,4-dichlorophenyl)thio]-1-[[4-[(dimethylamino)carbonyl]phenyl]methyl]-1H-indole-2-carboxylic acid |
| Anwendung: | Rheb inhibitor |
| CAS | 2216763-38-9 |
| MW: | 578.3 D |
ab 73,00 €
Rheb inhibitor NR1
Artikelnummer: TGM-T16741-100mg
Description: Rheb inhibitor NR1 is a selective mTORC1 inhibitor that suppresses the phosphorylation of T389pS6K1 and enhances the phosphorylation of S473pAKT. Target: mTOR. Smiles: CN(C)C(=O)c1ccc(Cn2c(cc3c(Br)cc(Sc4ccc(Cl)c(Cl)c4)cc23)C(O)=O)cc1. References: Mahoney SJ, et al. A small molecule inhibitor of Rheb...
| Anwendung: | Selective mTORC1 inhibitor |
| CAS | 2216763-38-9 |
| MW: | 578.3 D |
ab 38,00 €
