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Glutathione Peroxidase Assay Kit
Glutathione Peroxidase Assay Kit

Artikelnummer: Cay703102-96

Glutathione peroxidase (GPX) catalyzes the reduction of hydroperoxides, including hydrogen peroxides, by reduced glutathione and functions to protect the cell from oxidative damage. With the exception of phospholipid-hydroperoxide GPX, a monomer, all of the GPX enzymes are tetramers of four identical subunits. Each...
Schlagworte: GPX Assay Kit
Anwendung: GTx activity detection
ab 357,00 €
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Rosiglitazone
Rosiglitazone

Artikelnummer: Cay71740-10

Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) that binds to the ligand binding domain (LBD) of PPARgamma with a Kd value of 43 nM. It selectively activates chimeras containing the LBDs of PPARgamma over PPARalpha and PPARdelta in a cell-based reporter...
Schlagworte: BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Anwendung: PPARgamma agonist
CAS 122320-73-4
MW: 357.4 D
ab 35,00 €
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L-Buthionine-(S,R)-Sulfoximine
L-Buthionine-(S,R)-Sulfoximine

Artikelnummer: Cay14484-1

L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki 98%. Formulation: A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: O=S(CCCC)(CC[C@H](N)C(O)=O)=N. InChi Code:...
Schlagworte: BSO, NSC 326231, 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid
Anwendung: Oxidative stress inducer
CAS 83730-53-4
MW: 222.3 D
ab 82,00 €
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Glutathione Reductase Assay Kit
Glutathione Reductase Assay Kit

Artikelnummer: Cay703202-96

Glutathione reductase (GR, EC 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG) to glutathione (GSH). This enzyme is essential for the GSH redox cycle which maintains adequate levels of reduced cellular GSH. A high GSH/GSSG ratio is essential for protection...
Schlagworte: GR Assay Kit
Anwendung: GR activity detection
282,00 €
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Erastin
Erastin

Artikelnummer: Cay17754-5

Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
Schlagworte: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Anwendung: Antitumor agent
CAS 571203-78-6
MW: 547.1 D
ab 44,00 €
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tetrahydro-L-Biopterin (hydrochloride)
tetrahydro-L-Biopterin (hydrochloride)

Artikelnummer: Cay81880-100

tetrahydro-L-Biopterin (BH4) is a cofactor that, in the presence of enzyme site iron, binds to phenylalanine hydroxylase, tryptophan or tyrosine hydroxylase, and nitric oxide synthase (NOS), to facilitate the production of aromatic amino acids, neurotransmitters, and nitric oxide (NO), respectively. It is formed de...
Schlagworte: BH4, 2-amino-6R-(1R,2S-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone, dihydrochloride
Anwendung: NOS cofactor
CAS 69056-38-8
MW: 314.2 D
ab 37,00 €
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FSP1 Fluorescent Inhibitor Screening Assay Kit
FSP1 Fluorescent Inhibitor Screening Assay Kit

Artikelnummer: Cay701900-96

Cayman's FSP1 Fluorescent Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human FSP1, a negative regulator of the ferroptosis pathway. The assay measures the reduction of resazurin by FSP1 into resorufin, which can be easily quantified using a fluorescence...
Schlagworte: AMID, FSP1, p53-responsive gene 3 protein, Ferroptosis suppressor protein 1, Apoptosis-inducing factor homologous...
Anwendung: Fluorometric/photometric inhibitor screening assay
ab 563,00 €
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iFSP1
iFSP1

Artikelnummer: Cay29483-10

iFSP1 is an inhibitor of apoptosis inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1). It decreases cell viability in wild-type, but not glutathione peroxidase 4 (GPX4) knock-out, Pfa1 and HT1080 cells overexpressing AIFM2/FSP1, an effect that can be blocked by the ferroptosis...
Schlagworte: 1-amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Anwendung: AIFM2 inhibitor
CAS 150651-39-1
MW: 323.4 D
ab 32,00 €
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ML-162
ML-162

Artikelnummer: Cay20455-1

ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively). It shares a similar structure but is more potent and selective than (1S,3R)-RSL3 (Cay-19288), a previously reported inhibitor...
Schlagworte: alpha-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide
Anwendung: Antitumor agent
CAS 1035072-16-2
MW: 477.4 D
ab 32,00 €
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RC363
RC363

Artikelnummer: Cay31407-1

RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol (Cay-15043). It reduces 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals by approximately 40% in a cell-free assay when used at a concentration of 25 µM. RC363 prevents glutamate-induced toxicity...
Schlagworte: 2,6-bis(1,1-dimethylethyl)-4-(2-thienylthio)-phenol
Anwendung: Ferroptosis inhibitor
CAS 2584411-86-7
MW: 320.5 D
ab 44,00 €
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GPX4 Inhibitor Screening Assay Kit
GPX4 Inhibitor Screening Assay Kit

Artikelnummer: Cay701880-96

Cayman's GPX4 Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human GPX4, a negative regulator of the ferroptosis pathway. The assay measures GPX4 indirectly by a coupled reaction with glutathione reductase (GR). Oxidized glutathione (GSSG), produced upon...
Schlagworte: GPx-4, PHGPx, GSHPx-4, EC=1.11.1.12, Glutathione peroxidase 4, Phospholipid hydroperoxide glutathione peroxidase
Anwendung: Photometric inhibitor screening assay
563,00 €
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(1S,3R)-RSL3
(1S,3R)-RSL3

Artikelnummer: Cay19288-5

(1S,3R)-RSL3 is an inhibitor of glutathione peroxidase 4 (GPX4) that induces a lethal accumulation of lipid hydroperoxides and ferroptotic cell death (EC50 = 0.01 µM in HRASV12-expressing BJeHLT cells). It is selective for HRASV12-expressing over wild-type BJeHLT cells (EC50 = 2 µM). (1S,3R)-RSL3 reduces tumor...
Schlagworte: (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid,...
Anwendung: GPX4 inhibitor
CAS 1219810-16-8
MW: 440.9 D
ab 32,00 €
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