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Artikelnummer: Cay703102-96
Glutathione peroxidase (GPX) catalyzes the reduction of hydroperoxides, including hydrogen peroxides, by reduced glutathione and functions to protect the cell from oxidative damage. With the exception of phospholipid-hydroperoxide GPX, a monomer, all of the GPX enzymes are tetramers of four identical subunits. Each...
Schlagworte: | GPX Assay Kit |
Anwendung: | GTx activity detection |
ab 357,00 €
Artikelnummer: Cay71740-10
Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) that binds to the ligand binding domain (LBD) of PPARgamma with a Kd value of 43 nM. It selectively activates chimeras containing the LBDs of PPARgamma over PPARalpha and PPARdelta in a cell-based reporter...
Schlagworte: | BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
Anwendung: | PPARgamma agonist |
CAS | 122320-73-4 |
MW: | 357.4 D |
ab 35,00 €
Artikelnummer: Cay14484-1
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki 98%. Formulation: A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: O=S(CCCC)(CC[C@H](N)C(O)=O)=N. InChi Code:...
Schlagworte: | BSO, NSC 326231, 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid |
Anwendung: | Oxidative stress inducer |
CAS | 83730-53-4 |
MW: | 222.3 D |
ab 82,00 €
Artikelnummer: Cay703202-96
Glutathione reductase (GR, EC 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG) to glutathione (GSH). This enzyme is essential for the GSH redox cycle which maintains adequate levels of reduced cellular GSH. A high GSH/GSSG ratio is essential for protection...
Schlagworte: | GR Assay Kit |
Anwendung: | GR activity detection |
282,00 €
Artikelnummer: Cay17754-5
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
Schlagworte: | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
Anwendung: | Antitumor agent |
CAS | 571203-78-6 |
MW: | 547.1 D |
ab 44,00 €
Artikelnummer: Cay81880-100
tetrahydro-L-Biopterin (BH4) is a cofactor that, in the presence of enzyme site iron, binds to phenylalanine hydroxylase, tryptophan or tyrosine hydroxylase, and nitric oxide synthase (NOS), to facilitate the production of aromatic amino acids, neurotransmitters, and nitric oxide (NO), respectively. It is formed de...
Schlagworte: | BH4, 2-amino-6R-(1R,2S-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone, dihydrochloride |
Anwendung: | NOS cofactor |
CAS | 69056-38-8 |
MW: | 314.2 D |
ab 37,00 €
Artikelnummer: Cay701900-96
Cayman's FSP1 Fluorescent Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human FSP1, a negative regulator of the ferroptosis pathway. The assay measures the reduction of resazurin by FSP1 into resorufin, which can be easily quantified using a fluorescence...
Schlagworte: | AMID, FSP1, p53-responsive gene 3 protein, Ferroptosis suppressor protein 1, Apoptosis-inducing factor homologous... |
Anwendung: | Fluorometric/photometric inhibitor screening assay |
ab 563,00 €
Artikelnummer: Cay29483-10
iFSP1 is an inhibitor of apoptosis inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1). It decreases cell viability in wild-type, but not glutathione peroxidase 4 (GPX4) knock-out, Pfa1 and HT1080 cells overexpressing AIFM2/FSP1, an effect that can be blocked by the ferroptosis...
Schlagworte: | 1-amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile |
Anwendung: | AIFM2 inhibitor |
CAS | 150651-39-1 |
MW: | 323.4 D |
ab 32,00 €
Artikelnummer: Cay20455-1
ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively). It shares a similar structure but is more potent and selective than (1S,3R)-RSL3 (Cay-19288), a previously reported inhibitor...
Schlagworte: | alpha-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide |
Anwendung: | Antitumor agent |
CAS | 1035072-16-2 |
MW: | 477.4 D |
ab 32,00 €
Artikelnummer: Cay31407-1
RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol (Cay-15043). It reduces 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals by approximately 40% in a cell-free assay when used at a concentration of 25 µM. RC363 prevents glutamate-induced toxicity...
Schlagworte: | 2,6-bis(1,1-dimethylethyl)-4-(2-thienylthio)-phenol |
Anwendung: | Ferroptosis inhibitor |
CAS | 2584411-86-7 |
MW: | 320.5 D |
ab 44,00 €
Artikelnummer: Cay701880-96
Cayman's GPX4 Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human GPX4, a negative regulator of the ferroptosis pathway. The assay measures GPX4 indirectly by a coupled reaction with glutathione reductase (GR). Oxidized glutathione (GSSG), produced upon...
Schlagworte: | GPx-4, PHGPx, GSHPx-4, EC=1.11.1.12, Glutathione peroxidase 4, Phospholipid hydroperoxide glutathione peroxidase |
Anwendung: | Photometric inhibitor screening assay |
563,00 €
Artikelnummer: Cay19288-5
(1S,3R)-RSL3 is an inhibitor of glutathione peroxidase 4 (GPX4) that induces a lethal accumulation of lipid hydroperoxides and ferroptotic cell death (EC50 = 0.01 µM in HRASV12-expressing BJeHLT cells). It is selective for HRASV12-expressing over wild-type BJeHLT cells (EC50 = 2 µM). (1S,3R)-RSL3 reduces tumor...
Schlagworte: | (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid,... |
Anwendung: | GPX4 inhibitor |
CAS | 1219810-16-8 |
MW: | 440.9 D |
ab 32,00 €