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COVID-19 Forschung
PLpro (SARS Coronavirus) (rec.) (His)
PLpro (SARS Coronavirus) (rec.) (His)

Artikelnummer: SBB-DE0024-C050

The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or...
Schlagworte: Papain-like Proteinase, SARS Coronavirus Main Proteinase, Non-structural Protein 3, PL2-PRO, Nsp3
Anwendung: Assays
Reaktivität: Sars-cov
MW: 37 kD
222,00 €
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COVID-19 Forschung
Remdesivir
Remdesivir

Artikelnummer: Cay30354-5

Remdesivir is a prodrug form of the antiviral nucleoside analog GS-441524 (Cay-30469). Upon entry into cells, remdesivir is metabolized into the nucleotide triphosphate GS-441524. Remdesivir is active against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV)...
Schlagworte: GS-5734, N-[(S)-hydroxyphenoxyphosphinyl)-L-alanine, 2-ethylbutyl ester, 6-ester with...
Anwendung: GS-441524 prodrug, SARS type antiviral
CAS 1809249-37-3
MW: 602.6 D
ab 110,00 €
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COVID-19 Forschung
SARS-CoV-2 Inhibitor Screening Kit
SARS-CoV-2 Inhibitor Screening Kit

Artikelnummer: AG-48B-0001-KI01

To screen compounds that inhibit the binding of the viral protein SARS-CoV-2 Spike Protein (RBD) to its human receptor ACE2. Coronaviruses (CoVs) are enveloped non-segmented positive-sense single-stranded RNA viruses and can infect respiratory, gastrointestinal, hepatic and central nervous system of human and many...
Schlagworte: COVID-19 Inhibitor Screening Kit, 2019-nCoV Inhibitor Screening Kit, 2019-nCoV Spike Protein S1 (RBD)/ACE2 Inhibitor...
Anwendung: Compound Screening
Reaktivität: Human
715,00 €
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COVID-19 Forschung
ACE2, His-Tag
ACE2, His-Tag

Artikelnummer: BPS-11003-1

Human Angiotensin converting enzyme 2 (ACE2) also known ACEH, GenBank Accession No. NP_068576.1, a.a. 18-740, with a C-terminal His-tag, expressed in a HEK293 expression system. MW=85 kDa.
Schlagworte: ACE2, ACEH, angiotensin I converting enzyme 2, sars, sars protease, coronavirus, ncov
Anwendung: Exopeptidase, Enzyme kinetics, Inhibitor screening, Protein-protein interaction studies
Reaktivität: Human
MW: 85 kD
ab 380,00 €
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COVID-19 Forschung
SARS-CoV-2 (2019-nCoV) Papain-Like Protease Protein , recombinant
SARS-CoV-2 (2019-nCoV) Papain-Like Protease Protein ,...

Artikelnummer: E-PKSR030472.50

GenBank: QHD43415.1. Nsp3 is responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in...
Schlagworte: Non-structural protein 3, nsp3, PL2-PROPapain-like proteinase, PL-PRO, SARS coronavirus main proteinase
Reaktivität: Sars-cov-2
MW: 34 kD
ab 240,00 €
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COVID-19 Forschung
ACE2:SARS-CoV-2 Spike Inhibitor Screening Assay Kit
ACE2:SARS-CoV-2 Spike Inhibitor Screening Assay Kit

Artikelnummer: BPS-79936

The ACE2:SARS-CoV-2 Spike Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this interaction. The key to this kit is the high sensitivity of detection of bound Fc-tagged Spike protein by HRP-labeled Anti-Fc. Only a few simple steps on a microtiter plate are required for the assay....
Schlagworte: SARS-Coronavirus-2 spike protein binding, Angiotensin-converting enzyme 2, EC=3.4.17.23, ACEH, Angiotensin-converting...
Anwendung: SARS-CoV-2 Spike / ACE2 binding inhibitor screening
Reaktivität: Human
756,00 €
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COVID-19 Forschung
Aktion
Anti-SARS-CoV Nucleocapsid (N) Protein
Anti-SARS-CoV Nucleocapsid (N) Protein

Artikelnummer: 200-401-A50

Protein function: Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. [The UniProt Consortium]
Schlagworte: Anti-N, Anti-NC, Anti-9a, Anti-Protein N, Anti-Nucleoprotein, Anti-Nucleocapsid protein
Anwendung: ELISA, WB, IF
590,00 €
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COVID-19 Forschung
E-64
E-64

Artikelnummer: 51363.10

Purity: >99% (HPLC). Cell-permeable and irreversible inhibitor of calpain and other cystein proteases. Soluble in aqueous solutions. Stock solution: 1 mM, stable for months at -20 °C. Effective concentration: 1-10 µM.
Schlagworte: E-64, Aloxistatin
Anwendung: Inhibitor of cysteine proteases
CAS 66701-25-5
ab 72,00 €
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COVID-19 Forschung
Ruxolitinib
Ruxolitinib

Artikelnummer: AG-CR1-3624-M025

White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...
Schlagworte: INCB018424, INC 424
Anwendung: JAK1 inhibitor, JAK2 inhibitor
CAS 941678-49-5
MW: 306,4 D
ab 72,00 €
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COVID-19 Forschung
E-64d
E-64d

Artikelnummer: Cay13533-1

Cysteine proteases are a class of enzymes containing an active-site cysteine residue that is important in protein degradation pathways. E-64d, a synthetic analog of E-64 and ethyl ester of E-64c, is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases. E-64d inhibits calpain...
Schlagworte: Aloxistatin, E-64c ethyl ester, EP 453, EST, Loxistatin, NSC 694281,...
Anwendung: Protease inhibitor
CAS 88321-09-9
MW: 342.4 D
ab 44,00 €
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COVID-19 Forschung
Auranofin
Auranofin

Artikelnummer: Cay15316-25

Auranofin is a gold-thiol complex with anti-inflammatory and immunosuppressive actions. It potently inhibits thioredoxin reductase (IC50 = 0.2 µM), preventing reduction of thioredoxin and altering oxidative signaling relevant to DNA synthesis, transcription, apoptosis, and disease. Auranofin blocks LPS-mediated...
Schlagworte: NSC 321521, Ridauragold thiol, SKF 39162, [1-(thio-kappaS)-beta-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-gold
Anwendung: Thioredoxin reductase inhibitor
CAS 34031-32-8
MW: 678.5 D
ab 48,00 €
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COVID-19 Forschung
Hydroxychloroquine (sulfate)
Hydroxychloroquine (sulfate)

Artikelnummer: Cay17911-50

Hydroxychloroquine (HCQ) is a synthetic quinine derivative commonly used as an antimalarial drug. It is also useful in managing systemic lupus erythematosus, rheumatoid arthritis, and other diseases. HCQ inhibits autophagy and induces autophagic cell death (IC50 = 30 µM), suggesting potential applications in...
Schlagworte: HCQ, NSC 4375, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-ethanol, monosulfate
Anwendung: Antimalarial, Lupus erythematosus suppressant
CAS 747-36-4
MW: 434 D
ab 32,00 €
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