Vascular Endothelial Growth Factor-121, human recombinant, His Tag (rHuVEGF-121-His)

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. (www.uniprot.org) Produced in E.coli as a double, non-glycosylated, polypeptide chain containing a total of 142 amino acids. The VEGF-121 is fused to 20 amino acid His tag at N-terminus.