Transforming Growth Factor ß-2/TGFB2 Protein (recombinant human)

Activity: Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells.The ED50 for this effect is less than 15 ng/ml. Protein Construction: Recombinant Human Transforming Growth Factor beta 2 is produced by our Mammalian expression system and the target gene encoding Ala303-Ser414 is expressed. Sequence: Ala303-Ser414. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 12 kDa. Protein function: Transforming growth factor beta-2 (TGF-ß2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). Protein function: Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. [The UniProt Consortium]