Stromal Cell-Derived Factor-1 alpha (CXCL12), human recombinant (rHuSDF-1a)

Stromal Cell-Derived Factor-1 alpha (CXCL12), human recombinant (rHuSDF-1a)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
94842.2 2 µg - -

3 - 10 Werktage*

94,00 €
94842.10 10 µg - -

3 - 10 Werktage*

208,00 €
94842.1 1 mg - -

3 - 10 Werktage*

3.952,00 €
 
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C... mehr
Produktinformationen "Stromal Cell-Derived Factor-1 alpha (CXCL12), human recombinant (rHuSDF-1a)"
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase. (www.uniprot.org) Produced in E.coli as a non-glycosylated, polypeptide chain containing 68 amino acids. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development.
Schlagworte: SDF-1, CXCL12, Pre-B cell growth-stimulating factor, PBSF, hIRH, chemokine (C-X-C motif) ligand 12, SDF1, SDF1A, TPAR1, SCYB12, SDF-1a, TLSF-a
Hersteller: Biomol GmbH
Hersteller-Nr: 94842

Eigenschaften

Anwendung: Chemoattract.
Konjugat: No
Wirt: E.coli
Spezies-Reaktivität: human
MW: 8004.00 D
Format: Lyophilized

Datenbank Information

KEGG ID : K10031 | Passende Produkte
UniProt ID : P48061 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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