Stromal Cell-Derived Factor-1 alpha (CXCL12), His Tag, human recombinant (rHuSDF1a-His)

Stromal Cell-Derived Factor-1 alpha (CXCL12), His Tag, human recombinant (rHuSDF1a-His)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
97330.2 2 µg - -

3 - 10 Werktage*

94,00 €
97330.10 10 µg - -

3 - 10 Werktage*

208,00 €
97330.1 1 mg - -

3 - 10 Werktage*

5.824,00 €
 
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C... mehr
Produktinformationen "Stromal Cell-Derived Factor-1 alpha (CXCL12), His Tag, human recombinant (rHuSDF1a-His)"
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase. (www.uniprot.org) Recombinant human Stromal Cell-Derived Factor-1 alpha produced in E.coli is a non-glycosylated, polypeptide chain containing 78 amino acids, having a molecular mass of 9.2 kDa. The SDF-1a is fused to 10 amino acids His-Tag at N-terminus. SDF-1 (stromal cell-derived factor-1) is small cytokine belonging to the chemokine family that is officially designated Chemokine (C-X-C motif) ligand 12 (CXCL12). It is produced in two forms, SDF-1alpha/CXCL12a and SDF-1beta/CXCL12b, by alternate splicing of the same gene. Chemokines are characterized by the presence of four conserved cysteines, which form two disulfide bonds. The CXCL12 proteins belong to the group of CXC chemokines, whose initial pair of cysteines are separated by one intervening amino acid. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development. During embryogenesis it directs the migration of hematopoietic cells from foetal liver to bone marrow. Mice which were knocked-out for CXCL12 gene were lethal before the birth or within just 1 hour of life. As another role, CXCL12a alters also the electrophysiology of neurons. CXCL12 was shown to be expressend in many tissues in mice (including brain, thymus, heart, lung, liver, kidney, spleen and bone marrow).
Schlagworte: SDF-1, CXCL12, Pre-B cell growth-stimulating factor, PBSF, hIRH, chemokine (C-X-C motif) ligand 12, SDF1, SDF1A, TPAR1, SCYB12, SDF-1a, TLSF-a
Hersteller: Biomol GmbH
Hersteller-Nr: 97330

Eigenschaften

Anwendung: Bioassay
Konjugat: No
Wirt: E.coli
Spezies-Reaktivität: human
MW: 9200 D
Format: Purified

Datenbank Information

KEGG ID : K10031 | Passende Produkte
UniProt ID : P48061 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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