SerpinF1 / PEDF Protein (His Tag) (recombinant rat)

SerpinF1 / PEDF Protein (His Tag) (recombinant rat)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSR030156.100 100 µg -

7 - 16 Werktage*

895,00 €
 
Protein Construction: A DNA sequence encoding the rat Serpinf1 (NP_808788.1) (Met1-Thr418) was... mehr
Produktinformationen "SerpinF1 / PEDF Protein (His Tag) (recombinant rat)"
Protein Construction: A DNA sequence encoding the rat Serpinf1 (NP_808788.1) (Met1-Thr418) was expressed with a polyhistidine tag at the C-terminus. Sequence: Met1-Thr418. Fusion tag: C-His Endotoxin: < 1.0 EU per µg protein as determined by the LAL method. Protein function: Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
Schlagworte: Alpha-2 antiplasmin, Serpin family F member 1, Serine (Or cysteine) peptidase inhibitor, clade F, member 1, Serine (Or cysteine) peptidase inhibitor, clade F, member 1, isoform CRA_c, Recombinant Rat SerpinF1 / PEDF Protein (His Tag)
Hersteller: Elabscience
Hersteller-Nr: E-PKSR030156

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: rat
MW: 45.9 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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