Serpin F1/PEDF Protein(C-6His) (recombinant human)

Serpin F1/PEDF Protein(C-6His) (recombinant human)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH033042.10 10 µg -

7 - 16 Werktage*

152,00 €
E-PKSH033042.50 50 µg -

7 - 16 Werktage*

446,00 €
 
Protein Construction: Recombinant Human Serine Protease Inhibitor-clade F1 is produced by our... mehr
Produktinformationen "Serpin F1/PEDF Protein(C-6His) (recombinant human)"
Protein Construction: Recombinant Human Serine Protease Inhibitor-clade F1 is produced by our Mammalian expression system and the target gene encoding Gln20-Pro418 is expressed with a 6His tag at the C-terminus. Sequence: Gln20-Pro418. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 50 kDa. Protein function: Serpin F1 is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. Serpin F1 is a new promising approach for the treatment of osteosarcoma and has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Levels of the natural ocular anti-angiogenic factor SentrinF1 (PEDF) is associated with proliferative retinopathy. Protein function: Neurotrophic protein, induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. [The UniProt Consortium]
Schlagworte: PEDF, PIG35, EPC-1, SERPINF1, Serpin F1, Pigment epithelium-derived factor, Cell proliferation-inducing gene 35 protein, Recombinant Human Serpin F1/PEDF Protein(C-6His)
Hersteller: Elabscience
Hersteller-Nr: E-PKSH033042

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: human
MW: 45.4 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: +4°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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