Recombinant Human TGFBR2 Protein (Fc Tag) (RPES4049)

Recombinant Human TGFBR2 Protein (Fc Tag) (RPES4049)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4049.10 10 µg - - -

9 - 20 Werktage*

206,00 €
 
Recombinant Human TGFBR2 Protein (Fc Tag) from Assay Genie. Recombinant Human TGFBR2 Protein (Fc... mehr
Produktinformationen "Recombinant Human TGFBR2 Protein (Fc Tag) (RPES4049)"
Recombinant Human TGFBR2 Protein (Fc Tag) from Assay Genie. Recombinant Human TGFBR2 Protein (Fc Tag) is a highly purified recombinant protein produced in Human Cells and for the use in functional assays from Assay Genie.. Protein function: Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. [The UniProt Consortium]
Schlagworte: TGFR-2, TGFBR2, TbetaR-II, EC=2.7.11.30, TGF-beta receptor type-2, TGF-beta receptor type II, TGF-beta type II receptor, Transforming growth factor-beta receptor type II
Hersteller: Assay Genie
Hersteller-Nr: RPES4049

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K04388 | Passende Produkte
UniProt ID : P37173 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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