Recombinant Human KEAP1/INRF2 Protein (His & GST & AVI Tag) (RPES4319)

Recombinant Human KEAP1/INRF2 Protein (His & GST & AVI Tag) (RPES4319)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4319.50 50 µg - - -

9 - 20 Werktage*

524,00 €
 
Recombinant Human KEAP1/INRF2 Protein (His & GST & AVI Tag) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human KEAP1/INRF2 Protein (His & GST & AVI Tag) (RPES4319)"
Recombinant Human KEAP1/INRF2 Protein (His & GST & AVI Tag) from Assay Genie. Recombinant Human KEAP1/INRF2 Protein (His & GST & AVI Tag) is a highly purified recombinant protein produced in Baculovirus-Insect Cells and for the use in functional assays from Assay Genie.. Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:19489739, PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835). [The UniProt Consortium]
Schlagworte: INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1
Hersteller: Assay Genie
Hersteller-Nr: RPES4319

Eigenschaften

Konjugat: No
Exprimiert in: Insect cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K10456 | Passende Produkte
UniProt ID : Q14145 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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