PEDF (Pigment Epithelium-Derived Factor), human recombinant (rHuPEDF)

Neurotrophic protein. induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated, polypeptide chain containing 400 amino acids.