Osteoprotegerin, His Tag, human recombinant (rHuOPG-His)

Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated, polypeptide chain containing amino acids 201-401 of human OPG