Mouse IL10 recombinant protein (Active)

Mouse IL10 recombinant protein (Active)
%
Rabattaktion
Aktion:

Sichern Sie sich 20% Rabatt auf alle rekombinanten Proteine von Arigo Biolaboratories!

*1
*1 Angebot gültig bis zum 15.04.2024
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
ARG70161.20 20 µg - -

6 - 14 Werktage*

20 %
336,00 €
268,80 €
ARG70161.100 100 µg - -

6 - 14 Werktage*

20 %
840,00 €
672,00 €
 
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system... mehr
Produktinformationen "Mouse IL10 recombinant protein (Active)"
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (PubMed:28473584). [The UniProt Consortium]
Schlagworte: CSIF, Il10, Il-10, IL-10, Interleukin-10, Cytokine synthesis inhibitory factor
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG70161

Eigenschaften

Anwendung: SDS-PAGE, Cell culture
Konjugat: No
Spezies-Reaktivität: mouse
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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