Macrophage Inflammatory Protein-1 beta (CCL4), human recombinant (rHuMIP-1b)

Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8 T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated, polypeptide chain containing 69 amino acids. CCL3 and CCL4 are major factors produced by macrophages after they are stimulated with bacterial endotoxins.