LEC/NCC-4 (CCL16), human recombinant (rHuCCL16)

LEC/NCC-4 (CCL16), human recombinant (rHuCCL16)
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
97326.5 5 µg - -

1 - 10 Werktage

71,00 €
97326.20 20 µg - -

1 - 10 Werktage

184,00 €
97326.1 1 mg - -

1 - 10 Werktage

-
 
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent... mehr
Produktinformationen "LEC/NCC-4 (CCL16), human recombinant (rHuCCL16)"

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. (www.uniprot.org) Recombinant human CCL16 produced in E.coli is a non-glycosylated, polypeptide chain containing 97 amino acids and having a molecular mass of 11.2 kDa. Human CCL16, also called HCC-4, liver-expressed chemokine (LEC), and lymphocyte and monocyte chemoattractant (LMC), is a novel CC chemokine recognized by bioinformatics. NCC-4 cDNA encodes a 120 amino acids along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. HCC4 is vaguely related to other CC chemokines, showing less than 30% sequence identity. Among CC chemokines, CCL-16 has the largest similarity to HCC-1. 2 potential polyadenylation signals are present on the human HCC-4 gene, and as a result, 2 transcripts containing roughly 1,500 base pairs and 500 base pairs have been detected. HCC-4 is expressed weakly by some lymphocytes, including NK cells, T cells, and some T cell clones. The expression of HCC-4 in monocytes is greatly upregulated in the presence of IL-10. CCL16 shows chemotactic activity for lymphocytes and monocytes rather than to neutrophils. NCC-4 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16 demonstrates chemotactic activity for monocytes and thp-1 monocytes, rather than for resting lymphocytes and neutrophils. HCC-4 induces a calcium flux in thp-1 cells that desensitized prior to the expression of rantes.

Schlagworte: C-C motif chemokine 16, Small-inducible cytokine A16, IL-10-inducible chemokine, Chemokine LEC, Monotactin-1, Chemokine CC-4, Lymphocyte and monocyte chemoattractant, CCL-16, HCC-4, HCC4, NCC4, NCC-4, Liver Expressed Chemokine, LMC, LCC-1, LCC1, MTN-1, MT
Hersteller: Biomol GmbH
Hersteller-Nr: 97326.1

Eigenschaften

Anwendung: Cell culture
Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
MW: 11200 D
Format: Purified

Datenbank Information

KEGG ID : K21093 | Finde Alternativen
UniProt ID : O15467 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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