Interleukin-33/IL-33 Protein(N-6His) (recombinant human)

Interleukin-33/IL-33 Protein(N-6His) (recombinant human)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH032642.10 10 µg - -

7 - 16 Werktage*

194,00 €
E-PKSH032642.50 50 µg - -

7 - 16 Werktage*

571,00 €
 
Protein Construction: Recombinant Human Interleukin-33 is produced by our E.coli expression... mehr
Produktinformationen "Interleukin-33/IL-33 Protein(N-6His) (recombinant human)"
Protein Construction: Recombinant Human Interleukin-33 is produced by our E.coli expression system and the target gene encoding Ser112-Thr270 is expressed with a 6His tag at the N-terminus. Sequence: Ser112-Thr 270. Fusion tag: N-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 21 kDa. Protein function: Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes, but almost undetectable in placenta. IL33 induces the production of T helper-2 (Th2)-associated cytokines. IL-33 is a cytokine that mediates its biological effects by binding to and signals through IL1RL1/ST2 and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-?B and MAP kinase signaling pathways that drive production of type 2 cytokines from polarized Th2 cells. Protein function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). [The UniProt Consortium]
Schlagworte: IL33, C9orf26, Recombinant Human Interleukin-33/IL-33 Protein(N-6His)
Hersteller: Elabscience
Hersteller-Nr: E-PKSH032642

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
MW: 20.3 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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