Interleukin-23, HEK, human recombinant (rHuIL-23-HEK)

Human recombinant IL-23 produced in HEK cells is a glycosylated disulfide linked homodimer, having a total molecular weight of 43kDa and 19kDa heterodimer. IL23 is composed of a subunit of the heterodimeric cytokine IL23 and the p40 subunit of interleukin 12 (IL12B). Interleukin-23 (IL-23) belongs to the IL-12 family and is produced by antigen presenting cells. IL-23 using IL12RB1 and IL-23R (specific for IL-23) can activate STAT and NF-kappaB pathways and stimulate the production of interferon-gamma.). IL-23 is known to take a vital part in the inflammation process and is associated with auto immune diseases. However, unlike IL12, which acts primarily on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.