Interleukin-17, His Tag, human recombinant (rHuIL-17-His)

Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. (www.uniprot.org) Human recombinant Interleukin-17A produced in E.coli is a single, non-glycosylated, polypeptide chain containing 132 amino acids (fragment 24-155) having a molecular weight of 21.5kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. IL-17 is a proinflammatory cytokine produced by activated T-cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.