IL-33 (oxidation resistant) (human) (rec.) (untagged)

IL-33 (oxidation resistant) (human) (rec.) (untagged)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
AG-40B-0160-C010 10 µg -

3 - 9 Werktage*

264,00 €
AG-40B-0160-C100 100 µg -

3 - 9 Werktage*

990,00 €
 
Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed... mehr
Produktinformationen "IL-33 (oxidation resistant) (human) (rec.) (untagged)"
Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3) / ERK2 (MAPK1), p38(MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy &, anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. IL-33 facilitates Treg expansion in vitro and in vivo. Recently, IL-33 has been involved in adipocyte differentiation. The biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by its oxidation (formation of two disulphide bridges), resulting in an extensive conformational change that disrupts the ST2 binding site. Mutations at amino acids C208S/C232S protect IL-33 from oxidation and increase its activity. Protein function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). [The UniProt Consortium]
Schlagworte: IL33, C9orf26, IL-33 (human) (C208S/C232S), Interleukin-33 (human) (C208S/C232S), IL-1F11, NF-HEV
Hersteller: AdipoGen Life Sciences
Hersteller-Nr: AG-40B-0160

Eigenschaften

Anwendung: Cell culture, Binding assays
Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
MW: 17 kD
Reinheit: >95%
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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