IL-23 (mouse):Fc (human) (rec.)

IL-23 (mouse):Fc (human) (rec.)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
CHI-MF-11123-C050 50 µg - -

3 - 9 Werktage*

418,00 €
 
The mouse IL-23 complex composed of the p40 subunit (aa 23-335) and the p19 subunit (aa 20-196)... mehr
Produktinformationen "IL-23 (mouse):Fc (human) (rec.)"
The mouse IL-23 complex composed of the p40 subunit (aa 23-335) and the p19 subunit (aa 20-196) is fused through a polypeptide linker to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. 0 Interleukin-23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R&beta:1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naie and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8-and CD8 subtypes, however only IL-23 can act directly on CD8 DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.
Schlagworte: Interleukin-23, Il12b, IL-12B, CLMF p40, IL-12 subunit p40, Interleukin-12 subunit beta, Cytotoxic lymphocyte maturation factor 40 kDa subunit, Il23a, IL-23-A, IL-23p19, IL-23 subunit alpha, Interleukin-23 subunit p19, Interleukin-23 subunit alpha
Hersteller: Chimerigen Laboratories
Hersteller-Nr: MF-11123

Eigenschaften

Anwendung: Bioassays
Konjugat: No
Wirt: Hamster cells
Spezies-Reaktivität: mouse
Reinheit: >98%
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "IL-23 (mouse):Fc (human) (rec.)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen