IL-1 beta / IL1B Protein (pro form, His tag) (recombinant human)

IL-1 beta / IL1B Protein (pro form, His tag) (recombinant human)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH031840.20 20 µg - -

7 - 16 Werktage*

307,00 €
E-PKSH031840.50 50 µg - -

7 - 16 Werktage*

616,00 €
 
Activity: Measured by its binding ability in a functional ELISA.2. Immobilized human IL1B at 10... mehr
Produktinformationen "IL-1 beta / IL1B Protein (pro form, His tag) (recombinant human)"
Activity: Measured by its binding ability in a functional ELISA.2. Immobilized human IL1B at 10 µg/mL (100 µl/well) can bind human IL1RThe EC50 of human IL1R1 is 0.198 µg/mL. Protein Construction: A DNA sequence encoding the pro form of human IL1ß (NP_000567.1) (Met 1-Ser 269) was fused with a polyhistidine tag at the N-terminus. Sequence: Met 1-Ser 269. Fusion tag: N-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 34 kDa. Protein function: Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy Protein function: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). [The UniProt Consortium]
Schlagworte: IL1F2, IL-1 beta, Catabolin, Interleukin-1 beta, Recombinant Human IL-1 beta / IL1B Protein (pro form, His tag)
Hersteller: Elabscience
Hersteller-Nr: E-PKSH031840

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
MW: 32.3 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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