Human CXCL12 / SDF1 recombinant protein (Active)

Human CXCL12 / SDF1 recombinant protein (Active)
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Rabattaktion
Aktion:

Sichern Sie sich 20% Rabatt auf alle rekombinanten Proteine von Arigo Biolaboratories!

*1
*1 Angebot gültig bis zum 15.04.2024
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
ARG70140.20 20 µg - -

6 - 14 Werktage*

20 %
336,00 €
268,80 €
ARG70140.100 100 µg - -

6 - 14 Werktage*

20 %
840,00 €
672,00 €
 
Protein function: Chemoattractant active on T-lymphocytes and monocytes but not neutrophils.... mehr
Produktinformationen "Human CXCL12 / SDF1 recombinant protein (Active)"
Protein function: Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell- dependent pre-B-cells. [The UniProt Consortium]
Schlagworte: SDF1, CXCL12
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG70140

Eigenschaften

Anwendung: SDS-PAGE, Cell culture
Konjugat: No
Spezies-Reaktivität: human
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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