GRO-alpha (CXCL1), human recombinant (rHuGRO-a)

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated, polypeptide chain containing 73 amino acids. CXCL1 plays a role in spinal cord development and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.