Angiotensinogen/Serpin A8/AGT Protein(C-6His) (recombinant human)

Protein Construction: Recombinant Human Serine Protease Inhibitor-clade A8 is produced by our Mammalian expression system and the target gene encoding Asp34-Ala485 is expressed with a 6His tag at the C-terminus. Sequence: Asp34-Ala485. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 60 kDa. Protein function: Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. Protein function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [The UniProt Consortium]