Adiponectin (rat, rec.)

Rat adiponectin (amino acids 16-244) is fused at the N-terminus to a FLAG(R)-tag. Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells. Liquid. 0.2µm-filtered solution in 30mM TRIS-Cl, pH 8.5. ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.