4-1BB Receptor, His Tag, human recombinant (rHu4-1BBr-His)

Human recombinant 4-1BBR produced in E.coli is a single, non-glycosylated polypeptide chain containing 193 amino acids (18-186) and having a molecular mass of 20kDa. 4-1BBR is fused to a 24 amino acid His-tag at N-terminus. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.