WTAP Protein (GST tag) (recombinant human)

WTAP Protein (GST tag) (recombinant human)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH030933.100 100 µg -

7 - 16 Werktage*

1.016,00 €
 
Protein Construction: A DNA sequence encoding the human WTAP isoform 2 (Q15007-2) (Met 1-Arg 151)... mehr
Produktinformationen "WTAP Protein (GST tag) (recombinant human)"
Protein Construction: A DNA sequence encoding the human WTAP isoform 2 (Q15007-2) (Met 1-Arg 151) was fused with the GST tag at the N-terminus. Sequence: Met 1-Arg 151. Fusion tag: N-GST Endotoxin: Please contact us for more information. Apparent Molecular Mass: 45 kDa. Protein function: Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, stabilization of mRNA, and cell growth. Knocking down endogenous WTAP increased Smooth muscle cells (SMCs) proliferation, because of increased DNA synthesis and G(1)/S phase transition, together with reduced apoptosis. These effects could be the result of WTAP suppressing the transcriptional activity of WT1 in SMCs. WTAP may thus also play a role in messenger RNA processing in mammalian cells, either dependent on or independent of its interaction with WT1. Protein function: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). [The UniProt Consortium]
Schlagworte: hFL(2)D, WT1-associated protein, Female-lethal(2)D homolog, Pre-mRNA-splicing regulator WTAP, Wilms tumor 1-associating protein, Recombinant Human WTAP Protein (GST tag)
Hersteller: Elabscience
Hersteller-Nr: E-PKSH030933

Eigenschaften

Konjugat: No
Wirt: E.coli
Spezies-Reaktivität: human
MW: 45 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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