VISTA (human):COMP (mouse) (rec.) (His)

VISTA (human):COMP (mouse) (rec.) (His)
%
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
AG-40B-0183-C050 50 µg -

3 - 9 Werktage*

10 %
451,00 €
405,90 €
 
Recombinant protein. The extracellular domain of human VISTA (aa 33-194) is fused at the... mehr
Produktinformationen "VISTA (human):COMP (mouse) (rec.) (His)"
Recombinant protein. The extracellular domain of human VISTA (aa 33-194) is fused at the C-terminus to the domain of the mouse cartilage oligomeric matrix protein (COMP) (aa 28-72) and a His Tag. Source/Host: HEK 293 cells. Purity: >95% (SDS-PAGE). Lyophilized. Contains PBS. Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. Recently, it has been reported that the recombinant VISTA protein needs to be multimerized to be active as soluble ligand. The protein VISTA (human):COMP (mouse) (with the extracellular domain of VISTA (human) fused to the pentamerization domain from the cartilage oligomeric matrix protein (COMP)), but not VISTA-Fc, functions as an immunosuppressive agonist in vivo inhibiting the proliferation of CD4+ T cells.
Schlagworte: V-type Immunoglobulin Domain-containing Suppressor of T Cell Activation, Platelet Receptor Gi24, Stress-induced Secreted Protein-1, Sisp-1, V-set Domain-containing Immunoregulatory Receptor
Hersteller: AdipoGen Life Sciences
Hersteller-Nr: AG-40B-0183

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: human
MW: 4055 D
Reinheit: >95% (SDS-PAGE)
Format: Solid

Datenbank Information

UniProt ID : Q9H7M9 | Passende Produkte
Gene ID GeneID 64115 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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