TRAF3IP3 PrEST Antigen

TRAF3IP3 PrEST Antigen
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-APrEST71617.100 100 µl - -

7 - 10 Werktage*

247,00 €
 
Protein function: Adapter protein that plays essential roles in both innate and adaptive... mehr
Produktinformationen "TRAF3IP3 PrEST Antigen"
Protein function: Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Plays also an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'- dependent ubiquitination of TBK1 (PubMed:32366851). [The UniProt Consortium] Buffer: PBS and 1M Urea, pH 7.4.
Schlagworte: T3JAM, TRAF3IP3, TRAF3-interacting protein 3, TRAF3-interacting JNK-activating modulator
Hersteller: Atlas Antibodies
Hersteller-Nr: APrEST71617

Eigenschaften

Anwendung: Control antigen
Konjugat: No
Wirt: E.coli
Spezies-Reaktivität: human

Datenbank Information

UniProt ID : Q9Y228 | Passende Produkte
Gene ID GeneID 80342 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C (avoid repeat freezing and thawing cycles)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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