ß-Defensin 1/DEFB1 Protein (recombinant human)

Protein Construction: Recombinant Human beta-Defensin 1 is produced by our E.coli expression system and the target gene encoding Gly22-Lys68 is expressed. Sequence: Gly22-Lys68. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 6 kDa. Protein function: ß-Defensin 1 (DEFB1) is a member of the ß-defensin family, which is highly expressed by epithelial cells. ß-defensins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal peptide. ß-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. ß-defensin 1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. Defects in ß-Defensin-1 contribute to asthma diagnosis, with apparent gender-specific effects in human. ß-defensin 1 may also play a role in the pathogenesis of severe sepsis. In addition, ß-defensin 1 is associated with induction profiles in gingival keratinocytes. Protein function: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). [The UniProt Consortium]