SETDB1, Recombinant, Human, aa1-397, GST-Tag (Histone-lysine N-Methyltransferase SETDB1)

SETDB1, Recombinant, Human, aa1-397, GST-Tag (Histone-lysine N-Methyltransferase SETDB1)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
375283.20 20 µg - -

3 - 19 Werktage*

455,00 €
375283.100 100 µg - -

3 - 19 Werktage*

713,00 €
 
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9'... mehr
Produktinformationen "SETDB1, Recombinant, Human, aa1-397, GST-Tag (Histone-lysine N-Methyltransferase SETDB1)"
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions. Source: Recombinant protein corresponding to aa1-397 from human SETDB1, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~71.7kD , AA Sequence: MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDLHKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLVLFFSTILEAEVGGGGT, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: ESET, SETDB1, KIAA0067, EC=2.1.1.43, H3-K9-HMTase 4, SET domain bifurcated 1, Lysine N-methyltransferase 1E, Histone H3-K9 methyltransferase 4, ERG-associated protein with SET domain, Histone-lysine N-methyltransferase SETDB1
Hersteller: United States Biological
Hersteller-Nr: 375283

Eigenschaften

Konjugat: No
MW: 71,7
Format: Highly Purified

Handhabung & Sicherheit

Lagerung: °C
Versand: °C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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