Serpin A3N Protein (His Tag) (recombinant mouse)

Protein Construction: Recombinant Mouse Serpin A3N is produced by our Mammalian expression system and the target gene encoding Phe21-Lys418 is expressed with a 6His tag at the C-terminus. Sequence: Phe21-Lys418. Fusion tag: C-His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 58 kDa. Protein function: Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to alpha1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic lymphocytes, providing a means to disable cellmediated immune responses.