SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain (recombinant, aa 21-243, 319-541) (His-tagged)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19. The SARS-CoV-2 spike glycoprotein, also known as the surface glycoprotein, is located on the outer envelope of the virion. It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs. The S1 subunit contains the receptor-binding domain (RBD), which binds to the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), and the S1 and S2 subunits are cleaved by the protease TMPRSS2 to facilitate viral fusion with the host cell membrane. In this way, ACE2 acts as the functional receptor for SARS-CoV-2. Cayman's SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain (recombinant, aa 21-243, 319-541) (His-tagged) protein can be used for ELISA, surface plasmon resonance (SPR), and Western blot (WB) applications.Synonyms: SARS-CoV-2 Spike RBD, SARS-CoV-2 Spike Receptor Binding Domain, Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein Receptor Binding Domain, Spike S1 RBD. Purity: >90%. Source: Active recombinant SARS-CoV-2 C-terminal His-tagged spike glycoprotein receptor binding domain expressed in HEK293 cells. Amino Acids: 21-243, 319-541 of P0DTC2. MW: 28.7 kDa. Formulation: (Request formulation change), PBS, pH 7.4, with 5% mannitol, 0.01% Tween 20, and 10% glycerol. UniProt Accession #: P0DTC2.